Migration Test Case

Clinical Vignette

A 45-year-old woman presents with fever and cough for 5 days. She reports subjective fevers, chills, and a productive cough with green sputum. She has no significant past medical history and takes no medications. She works as a teacher and has no recent travel history. On examination, temperature is 38.5°C, heart rate 110 bpm, blood pressure 120/80 mmHg, respiratory rate 24/min, oxygen saturation 92% on room air. Lung exam reveals crackles in the right lower lobe. Laboratory studies show leukocytosis with left shift. Chest X-ray shows right lower lobe consolidation.

The patient is started on empiric antibiotics. Blood cultures grow Gram-positive cocci in clusters. The organism is catalase-positive and coagulase-negative. She improves with antibiotic therapy and is discharged home after 5 days. This case demonstrates a common community-acquired pneumonia with bacteremia from a typical pathogen.

Chest X-ray showing right lower lobe consolidation

Chest X-ray showing right lower lobe consolidation.

Question 1

What is the most likely causative organism?

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Question 2

Which antibiotic would be most appropriate for empiric treatment?

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Answer the question above to reveal the rationale.
Answer the question above to reveal the rationale.

References

Metlay JP, Waterer GW, Long AC, et al. Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019;200(7):e45-e67.

DOI: https://doi.org/10.1164/rccm.201908-1581ST